Related Experiment Video

Updated: Aug 11, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

253

An Analysis of the Prevalence and Risk Factors of Contrast-Associated Acute Kidney Injury in Patients With Diabetic

Hüseyin Karaaslan1, Nida Uyar1, Ensar Gazi Göçer2

  • 1Department of Endocrinology, School of Medicine, Harran University, Sanliurfa, Turkey.

Angiology
|February 6, 2023
PubMed

Insights

Contrast-associated acute kidney injury (CA-AKI) is common in diabetic foot ulcer (DFU) patients undergoing contrast-enhanced computed tomographic angiography (CTA). Key risk factors include longer diabetes history and heart failure, necessitating preventive measures.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Contrast-associated acute kidney injury (CA-AKI) is a significant complication linked to renal dysfunction, diabetes mellitus (DM), and atherosclerotic cardiovascular diseases (ASCVD).
  • Diabetic foot ulcers (DFU) often coexist with ASCVD risk factors and comorbidities, suggesting a potential for high CA-AKI prevalence in this population.

Purpose of the Study:

  • To investigate the incidence of CA-AKI in patients hospitalized for DFU.
  • To identify risk factors associated with CA-AKI in DFU patients undergoing contrast-enhanced computed tomographic angiography (CTA).

Main Methods:

  • Retrospective analysis of 208 type 2 diabetic patients hospitalized for DFU.
  • Division into two groups: 107 patients undergoing CTA (group 1) and 101 control patients not receiving contrast media (group 2).
  • Monitoring of serum creatinine levels post-CTA to diagnose AKI.

Main Results:

  • CA-AKI developed in 12.1% of patients in group 1 (underwent CTA) compared to 3.0% in group 2 (no contrast), P = 0.013.
  • Identified risk factors for CA-AKI included longer DM history, elevated baseline serum creatinine, congestive heart failure, advanced Wagner stage DFUs (4-5), peripheral artery disease, older age, and lower hemoglobin.
  • AKI occurred in 13 patients after CTA, with 3 in the control group showing serum creatinine elevations.

Conclusions:

  • CA-AKI is a frequent complication following CTA in patients with DFU.
  • Recognizing and managing identified risk factors is crucial for preventing CA-AKI in this vulnerable patient group.

Keywords:
contrast-associated acute kidney injurydiabetic foot ulcerperipheral artery disease

More Related Videos

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.0K
Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
50
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
52
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
54
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
57
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
46
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
42