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Engineering a polymer-encapsulated manganese dioxide/upconversion nanoprobe for FRET-based hydrogen peroxide
Pingping Wan1, Huimin Fu1, Yi Zhang2
1School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
Analytical and Bioanalytical Chemistry
|February 6, 2023
Summary
Researchers developed a novel nanoprobe for detecting hydrogen peroxide (H2O2), a key disease biomarker. This sensitive and specific tool aids in early disease diagnosis and treatment by enabling real-time H2O2 monitoring in living organisms.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Hydrogen peroxide (H2O2) is a crucial biomarker in various diseases.
- Irregular H2O2 levels can cause significant health issues.
- Sensitive and specific detection methods are needed for early diagnosis and therapeutics.
Purpose of the Study:
- To design and develop a biocompatible nanoprobe for sensitive and specific detection of trace amounts of H2O2.
- To create a near-infrared (NIR) excited luminescent nanoprobe for real-time H2O2 monitoring.
Main Methods:
- Amphiphilic poly(styrene-co-maleic anhydride) (PMSA) was used to encapsulate upconversion nanoparticles (UCNPs) and manganese dioxide nanoparticles (MnO2 NPs).
- The nanoprobe's luminescence was measured based on the catalytic decomposition of MnO2 NPs by H2O2.
- Selectivity, biocompatibility, and water-dispersibility were evaluated.
Main Results:
- The nanoprobe exhibited luminescence recovery linearly dependent on H2O2 concentration.
- A low limit of detection (LOD) of 20 nM for H2O2 was achieved.
- The probe demonstrated high selectivity, biocompatibility, and water-dispersibility.
Conclusions:
- The developed PMSA-encapsulated UCNP/MnO2 NP nanoprobe is effective for sensitive and specific H2O2 detection.
- This technology holds promise for real-time monitoring of disease-related H2O2 in living systems.
- The nanoprobe facilitates early diagnosis and therapeutic strategies.
