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Synthesis of new N-alkyl-2-mercapto-1-octylamines and respective disulfides
S A Vieira Filho1, D L Nelson, D Piló-Veloso
1Departamento de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte.
Anais Da Academia Brasileira De Ciencias
|December 1, 1986
Abstract:
Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infection by Schistosoma mansoni, only 2,2'-dithiobis(N-isobutyl-1-octylamine) exhibited activity.