Heuristic Tree-Partition-Based Parallel Method for Biophysically Detailed Neuron Simulation

Biophysically detailed neuron simulation is a powerful tool to explore the mechanisms behind biological experiments and bridge the gap between various scales in neuroscience research. However, the extremely high computational complexity of detailed neuron simulation restricts the modeling and exploration of detailed network models. The bottleneck is solving the system of linear equations. To accelerate detailed simulation, we propose a heuristic tree-partition-based parallel method (HTP) to parallelize the computation of the Hines algorithm, the kernel for solving linear equations, and leverage the strong parallel capability of the graphic processing unit (GPU) to achieve further speedup. We formulate the problem of how to get a fine parallel process as a tree-partition problem. Next, we present a heuristic partition algorithm to obtain an effective partition to efficiently parallelize the equation-solving process in detailed simulation. With further optimization on GPU, our HTP method achieves 2.2 to 8.5 folds speedup compared to the state-of-the-art GPU method and 36 to 660 folds speedup compared to the typical Hines algorithm.