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Related Experiment Video

Updated: Aug 11, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Assisted Reproductive Techniques in Multiple Sclerosis: Recommendations from an Expert Panel.

Celia Oreja-Guevara1,2, Aintzane Rabanal3, Corazón Hernández Rodríguez4

  • 1Department of Neurology, Health Research Institute of the Hospital Clínico San Carlos (IdISSC), Hospital Clinico San Carlos, Madrid, Spain. orejacbn@gmail.com.

Neurology and Therapy
|February 6, 2023
PubMed
Summary
This summary is machine-generated.

This review provides guidelines for managing women with multiple sclerosis (MS) who desire motherhood, emphasizing assisted reproductive techniques (ART). Early counseling and multidisciplinary care are crucial for successful pregnancy planning in MS patients.

Keywords:
Assisted reproductive technologyGnRH antagonistsMultiple sclerosisOocyte cryopreservationPreconception counselling

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Area of Science:

  • Reproductive medicine
  • Neurology
  • Women's health

Background:

  • Multiple sclerosis (MS) predominantly affects women of reproductive age.
  • Lack of joint guidelines for neurologists and gynecologists managing MS in women desiring pregnancy.
  • Focus on assisted reproductive techniques (ART) for conception in MS patients.

Purpose of the Study:

  • To propose recommendations for managing women with MS desiring pregnancy.
  • To address specific considerations for those undergoing assisted reproductive techniques (ART).
  • To highlight the need for collaborative care between neurologists and gynecologists.

Main Methods:

  • Consensus reached by a panel of seven experts (4 neurologists, 3 gynecologists).
  • Three discussion sessions were conducted to establish recommendations.
  • Review focused on integrating neurological and gynecological management strategies.

Main Results:

  • Emphasis on early preconception counseling for women with MS.
  • Guidelines for managing disease-modifying therapies before and during ART.
  • Considerations for various ART procedures including intrauterine insemination, in vitro fertilization, and oocyte cryopreservation.
  • Importance of multidisciplinary units for patient management.

Conclusions:

  • Individualized pregnancy management for women with MS is essential, starting with preconception consultations.
  • Prioritizing well-planned, spontaneous pregnancies when feasible.
  • Multidisciplinary team management is vital for guiding women with MS through their pregnancy journey.