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Hydroxychloroquine Therapy in Sarcoidosis-Associated Uveitis
Arthur Bert1, Thomas El Jammal1, Laurent Kodjikian2
1Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University - Lyon 1, Lyon, France.
Ocular Immunology and Inflammation
|February 7, 2023
Summary
Hydroxychloroquine (HCQ) is effective for treating sarcoidosis-associated uveitis (SAU), reducing inflammation and corticosteroid use. While generally well-tolerated, some patients discontinued HCQ due to ineffectiveness or side effects.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Sarcoidosis-associated uveitis (SAU) is a chronic inflammatory condition affecting the eye.
- Management of SAU often requires long-term immunosuppressive therapy.
- Hydroxychloroquine (HCQ) is a commonly used disease-modifying antirheumatic drug (DMARD).
Purpose of the Study:
- To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in patients with sarcoidosis-associated uveitis (SAU).
- To assess the impact of HCQ on corticosteroid dosage and uveitis flare incidence.
Main Methods:
- Retrospective analysis of 27 patients with SAU treated with HCQ from 2003 to 2019.
- Data collected on treatment duration, efficacy, corticosteroid use, and adverse events.
- Statistical analysis to compare pre- and post-treatment outcomes.
Main Results:
- HCQ treatment achieved success in 55.6% of patients with SAU.
- Median prednisone dose significantly decreased from 20.0 to 5.0 mg/day (p=0.02).
- Incidence rate of uveitis flares reduced significantly (p=0.02); 44.4% discontinued HCQ due to ineffectiveness or side effects.
Conclusions:
- Hydroxychloroquine (HCQ) is a viable treatment option for sarcoidosis-associated uveitis (SAU).
- HCQ can lead to reduced corticosteroid dependence and fewer disease flares.
- Careful monitoring is necessary due to potential ineffectiveness or adverse events.
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