Related Experiment Video
Updated: Aug 11, 2025
10:35
Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
8.3K
Immune Mechanisms in Inflammatory Anemia
Susan P Canny1,2, Susana L Orozco1, Natalie K Thulin1,3
1Center for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA; email: jhamerman@benaroyaresearch.org, scanny@benaroyaresearch.org, sorozco@benaroyaresearch.org, nthulin@benaroyaresearch.org.
Annual Review of Immunology
|February 7, 2023
Summary
Inflammation disrupts red blood cell (RBC) balance, causing anemia. Immune mechanisms affecting RBC production and clearance are key factors in diseases like malaria and lupus.
Area of Science:
- Immunology and Hematology
- Pathophysiology of Anemia
Background:
- Red blood cell (RBC) homeostasis is vital for tissue oxygenation, maintained by erythropoiesis and macrophage clearance.
- Inflammatory conditions frequently dysregulate RBC homeostasis, leading to anemia through complex mechanisms.
Purpose of the Study:
- To elucidate common innate and adaptive immune mechanisms contributing to inflammatory anemias.
- To examine these mechanisms in diverse disease contexts, including infectious and autoimmune disorders.
Main Methods:
- Review of immune system interactions impacting RBC production and clearance during inflammation.
- Analysis of disease-specific examples: hemophagocytic lymphohistiocytosis/macrophage activation syndrome, severe malarial anemia, and systemic lupus erythematosus.
Main Results:
- Inflammatory cytokines and innate sensing pathways directly and indirectly affect RBC production and clearance.
- Multiple immune-driven mechanisms contribute synergistically to the development of anemia in inflammatory diseases.
Conclusions:
- Understanding immune involvement in RBC homeostasis disruption is crucial for managing inflammatory anemias.
- Targeting these immune pathways may offer therapeutic strategies for anemia associated with inflammation.
Related Concept Videos
01:01Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
01:30Inflammatory Response I: Vascular and Cellular
11.9K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.9K
01:28Inflammatory Response
3.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
3.8K
01:38Inflammation
54.3K
Overview
54.3K
01:27Disorders of Erythrocytes
1.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.0K
01:21Myocarditis I: Introduction
18
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
18