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Published on: August 7, 2015
Retinal determination gene networks: from biological functions to therapeutic strategies
Shuangli Zhu1, Wanling Li2,3, Hao Zhang1
1Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Abstract:
The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well as organogenesis. This network is not only associated with malignant biological behaviors of tumors, such as proliferation, and invasion, but also regulates the development of multiple mammalian organs. Three members of this conservative network have been extensively investigated, including DACH, SIX, and EYA. Dysregulated RDGN signaling is associated with the initiation and progression of tumors. In recent years, it has been found that the members of this network can be used as prognostic markers for cancer patients. Moreover, they are considered to be potential therapeutic targets for cancer. Here, we summarize the research progress of RDGN members from biological functions to signaling transduction, especially emphasizing their effects on tumors. Additionally, we discuss the roles of RDGN members in the development of organs and tissue as well as their correlations with the pathogenesis of chronic kidney disease and coronary heart disease. By summarizing the roles of RDGN members in human diseases, we hope to promote future investigations into RDGN and provide potential therapeutic strategies for patients.
Insights
The retinal determinant gene network (RDGN) regulates tumor progression and organ development. Its members, DACH, SIX, and EYA, show potential as cancer biomarkers and therapeutic targets.
Area of Science:
- Developmental Biology
- Cancer Biology
- Genetics
Background:
- The retinal determinant gene network (RDGN), crucial for eye specification in Drosophila, is conserved and plays roles in mammalian organogenesis and tumorigenesis.
- Key RDGN members (DACH, SIX, EYA) are implicated in malignant behaviors like tumor proliferation and invasion.
- Dysregulation of RDGN signaling is linked to cancer initiation and progression.
Purpose of the Study:
- To summarize research on RDGN members' biological functions and signaling pathways.
- To emphasize the role of RDGN in tumorigenesis and cancer progression.
- To discuss RDGN's involvement in organ development and its correlation with diseases like chronic kidney and coronary heart disease.
Main Methods:
- Literature review and synthesis of existing research on RDGN.
- Analysis of studies focusing on DACH, SIX, and EYA in various biological contexts.
- Examination of RDGN's role in cancer, organogenesis, and specific human diseases.
Main Results:
- RDGN members are associated with critical biological processes including proliferation and invasion in tumors.
- Dysregulated RDGN signaling contributes to cancer initiation and progression.
- RDGN members are emerging as potential prognostic markers and therapeutic targets for cancer patients.
Conclusions:
- RDGN plays a significant role in both normal organ development and the pathogenesis of various human diseases, particularly cancer.
- Understanding RDGN signaling pathways offers insights into disease mechanisms and potential therapeutic strategies.
- Further investigation into RDGN members is warranted to fully elucidate their roles and clinical applications.
