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Ileal signet-ring cell carcinoma with brain metastases: A case report
Jorge Cabrera-Montes1, Daniela Fuel-Gómez2, Monica Lara-Almunia1
1Department of Neurosurgery, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
Background:
Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that frequently originates in the stomach. Uncommonly, this tumor can lead to brain metastases; an event rarely reported in the literature.
Case Description:
A 76-year-old man with a history of cognitive impairment was diagnosed with two brain space-occupying lesions. A whole-body 18F-FDG PET/computed tomography scan revealed a hypermetabolic lesion in a segment of the ileum corresponding to mural thickening and an ulcerated lesion detected on colonoscopy. A brain biopsy, using an immunohistochemistry protocol, showed signet-ring cells with a pattern that suggested an intestinal origin. The diagnosis of SRCC brain metastases with an ileal origin was made, and a treatment protocol was designed. However, the patient rapidly deteriorated, and passed away shortly afterward.
Conclusion:
To the best of our knowledge, this is the first case report of an ileal SRCC with brain metastases.
