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Association between Psychiatric Disorders and Glomerular Disease.
Hailey E Desmond1, Clare Lindner1, Jonathan P Troost2
1Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Glomerular Diseases
|February 8, 2023
Summary
Psychiatric disorders affect 12% of patients with glomerular disease, particularly adolescents. These conditions correlate with disease severity and predict progression to end-stage kidney disease (ESKD), highlighting the need for mental health screening.
Area of Science:
- Nephrology
- Psychiatry
- Epidemiology
Background:
- Chronic kidney disease (CKD) increases psychiatric disorder risk.
- Limited data exist on psychiatric disorders in primary glomerular disease patients.
Purpose of the Study:
- To investigate the incidence of psychiatric disorders in patients with glomerular disease.
- To identify risk factors for psychiatric disorders in this population.
- To examine the association between psychiatric disorders and end-stage kidney disease (ESKD) progression.
Main Methods:
- Utilized data from 950 patients in the kidney research network multisite patient registry.
- Identified psychiatric disorders using ICD-9/10 codes and analyzed time to diagnosis via Cox proportional hazard models.
- Adjusted for confounders including age, sex, race, ethnicity, estimated glomerular filtration rate, and proteinuria (urine protein-to-creatinine ratio [UPCR]).
Main Results:
- 12% of participants were diagnosed with a psychiatric disorder over a median of 58 months.
- Adolescent age and Asian race were associated with psychiatric diagnosis.
- Higher UPCR and medication burden correlated with psychiatric disorders.
- Psychiatric diagnosis predicted progression to ESKD (HR = 2.45).
Conclusions:
- Psychiatric disorders are prevalent in glomerular disease patients, correlating with clinical factors.
- Mental health screening is recommended for all patients with glomerular disease, irrespective of age.
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