Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

867
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
867
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

163
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
163
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

31.0K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
31.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

132
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
132
Liver Physiology01:30

Liver Physiology

878
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
878
Liver Regeneration01:24

Liver Regeneration

3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The People-First Liver Charter.

Nature medicine·2025
Same author

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People With Diabetes: The Need for Screening and Early Intervention. A Consensus Report of the American Diabetes Association.

Diabetes care·2025
Same author

Awareness of metabolic dysfunction-associated steatotic liver disease (MASLD) in 4 major cities in the United States.

Hepatology communications·2025
Same author

Obesity and its management in primary care setting.

Journal of diabetes and its complications·2025
Same author

Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis.

Gastroenterology·2025
Same author

Interdisciplinary perspectives on the co-management of metabolic dysfunction-associated steatotic liver disease and coronary artery disease.

The lancet. Gastroenterology & hepatology·2024

Related Experiment Video

Updated: Aug 11, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.2K

Nonalcoholic Fatty Liver Disease.

Scott Isaacs1

  • 1Emory University School of Medicine, 775 Johnson Ferry Rad. NE, Atlanta, GA 30342, USA; Atlanta, GA, USA.

Endocrinology and Metabolism Clinics of North America
|February 8, 2023
PubMed
Summary

Managing nonalcoholic fatty liver disease (NAFLD) is vital for type 2 diabetes (T2D) remission due to shared insulin resistance. Early noninvasive testing and targeted treatments focusing on weight loss and lifestyle changes are key for better outcomes.

Keywords:
CirrhosisFIB-4Metabolic syndromeNAFLDNASHObesitySteatohepatitisType 2 diabetes

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

994
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

6.5K

Related Experiment Videos

Last Updated: Aug 11, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.2K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

994
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

6.5K

Area of Science:

  • Hepatology and Endocrinology
  • Metabolic Diseases Research

Background:

  • Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) share common pathophysiological mechanisms, including insulin resistance and lipotoxicity.
  • A significant portion of T2D patients (one in three) have nonalcoholic steatohepatitis, increasing risks for advanced liver conditions like fibrosis, cirrhosis, and hepatocellular carcinoma.

Purpose of the Study:

  • To highlight the critical link between NAFLD management and T2D remission.
  • To emphasize the role of noninvasive testing in assessing advanced liver disease risk.
  • To outline effective treatment strategies for NAFLD that align with T2D remission goals.

Main Methods:

  • Review of current literature on NAFLD and T2D pathophysiology and management.
  • Discussion of noninvasive diagnostic tools (imaging, serum biomarkers) for advanced liver disease.
  • Analysis of treatment modalities including lifestyle modification, pharmacotherapy, and bariatric surgery.

Main Results:

  • NAFLD and T2D are intrinsically linked, with NAFLD progression posing serious health risks.
  • Noninvasive testing effectively identifies patients at risk for advanced liver disease, reserving liver biopsy for select cases.
  • Integrated treatment approaches focusing on weight loss and comorbid condition management are essential.

Conclusions:

  • Effective management of NAFLD is paramount for achieving T2D remission.
  • Noninvasive assessments are crucial for risk stratification in patients with NAFLD and T2D.
  • Therapeutic strategies should encompass lifestyle changes, weight management, and appropriate T2D medications.