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Updated: Aug 11, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
How to lose resistance to Aspergillus infections
Jean-Pierre Gangneux1, Martin Hoenigl2, Nicolas Papon3
1Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, F-35000 Rennes, France; Laboratoire de Parasitologie et Mycologie Médicale, LA-AspC Centre National de Référence des Mycoses et Antifongiques, European Excellence Center for Medical Mycology (ECMM), Centre hospitalier Universitaire de Rennes, F-35000 Rennes, France.
Abstract:
The distinct risk factors to deadly infections by Aspergillus fumigatus (Af) in intensive care unit (ICU) patients are well known; however, so far, the mechanistic link between these predisposing conditions has been unknown. Sarden et al. recently unraveled a shared B1a lymphocyte-natural antibody-neutrophil defense pathway to Af, opening new perspectives in diagnostics and therapeutics.

