Related Experiment Video

Updated: Aug 11, 2025

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

10.8K

Evolution of pediatric pharmaceutical forms for treatment of Hansen's disease (leprosy)

Jocimar da Silva Santos1, Franciely da Costa Alves1, Efraim José Dos Santos Júnior1

  • 1Núcleo de Controle de Qualidade de Medicamentos e Correlatos, Department of Pharmacy, Universidade Federal de Pernambuco, Av. Prof. Arthur de Sá, S/N, Cidade Universitária, Recife PE, Brasil.

Expert Opinion on Therapeutic Patents
|February 9, 2023
PubMed

Insights

Innovative pharmaceutical formulations are being developed to improve leprosy treatment adherence and success in children. This research reviews global patents for pediatric leprosy drug delivery systems.

Area of Science:

  • Pharmaceutical Sciences
  • Pediatric Infectious Diseases
  • Drug Delivery Systems

Background:

  • Leprosy, caused by *Mycobacterium leprae*, is a chronic infectious disease often more severe in children.
  • Current standard treatments (rifampicin, clofazimine, dapsone) in solid forms lead to poor adherence and treatment failure in pediatric patients.
  • Despite numerous formulation technologies developed, challenges remain in optimizing pediatric leprosy therapy.

Approach:

  • A global patent review was conducted to analyze technological advancements in pharmaceutical treatments for pediatric leprosy.
  • Formulations were categorized by administration route: oral, inhalable, injectable, and transdermal.
  • Physicochemical drug properties and pediatric patient physiology were considered in organizing alternative formulations.

Key Points:

  • Patented innovative formulations offer diverse administration routes for pediatric leprosy treatment.
  • Key challenges include the physicochemical instability of drug formulations.
  • Addressing formulation optimization is crucial for therapeutic success in children.

Conclusions:

  • Technological evolution in pharmaceutical formulations presents new avenues for pediatric leprosy treatment.
  • Overcoming drug stability issues is critical for bringing innovative pediatric formulations to market.
  • Optimized formulations are essential to improve therapeutic outcomes and combat leprosy in pediatric populations.
Abstract

Keywords:
Pharmaceutical technologyclofaziminedapsonerifampicinroutes of drug administration

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.0K
Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs18:46

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

13.4K

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.1K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
813
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
362
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.7K
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.6K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
224