A membrane protein from IFN-beta-treated Daudi cells causes a cessation in cell growth

An interferon-induced 17 kDa protein has been partially purified from the membranes of interferon-beta-treated Daudi cells. A fraction containing the 17 kDa protein purified 200 fold causes an inhibition of growth of Daudi, Namalva and Hela cells. The same fraction purified from the membranes of untreated cells causes no inhibition of cell growth. This interferon-beta-induced protein is located on the exterior of Daudi cells for it can be labeled with [125I] iodine catalyzed by lactoperoxidase. These results suggest that interferons induce a cell surface protein whose role is to cause an inhibition of cell growth.