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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Autophagy-dependent ferroptosis in kidney disease
Yuanting Yang1, Jiayi Cheng2, Qisheng Lin1
1Molecular Cell Lab for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in Medicine
|February 9, 2023
Summary
Ferroptosis, a cell death linked to redox imbalance, involves autophagy in kidney diseases. This review explores autophagy-dependent ferroptosis mechanisms and their role in renal pathologies.
Area of Science:
- Biochemistry
- Cell Biology
- Pathology
Background:
- Ferroptosis is a novel form of regulated cell death.
- It is characterized by lipid peroxide accumulation due to GPX4 deficiency and redox imbalance.
- Key pathways include GPX4, System Xc-, lipid, and iron metabolism.
Purpose of the Study:
- To review the current research on autophagy-dependent ferroptosis.
- To highlight the role of autophagy-mediated ferroptosis in kidney diseases.
Main Methods:
- Literature review of recent studies on ferroptosis and autophagy.
- Analysis of molecular mechanisms linking autophagy and ferroptosis.
- Examination of ferroptosis's role in various kidney pathologies.
Main Results:
- Autophagy, through ferritinophagy, lipophagy, and clockophagy, modulates ferroptosis.
- Autophagy-dependent ferroptosis is implicated in the pathogenesis of neurological, liver, lung, and kidney diseases.
- Specific mechanisms of autophagy-ferroptosis interplay in kidney disease are emerging.
Conclusions:
- Autophagy-dependent ferroptosis is a critical process in kidney disease development.
- Targeting this pathway offers potential therapeutic strategies for renal pathologies.
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