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Evidence for Utilization of Injectable Biologic Augmentation in Primary Rotator Cuff Repair: A Systematic Review of
Olivia J Bono1, Bryan Jenkin2, Julianne Forlizzi3
1Albany Medical College, Albany, New York, USA.
Orthopaedic Journal of Sports Medicine
|February 9, 2023
Summary
Injectable biologics show promise for improving rotator cuff repair outcomes. Studies suggest enhanced tissue quality and reduced retear rates with growth factors, stem cells, and platelet-rich plasma (PRP).
Area of Science:
- Orthopedic Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Rotator cuff repair healing is challenging.
- Injectable biologics may enhance tissue quality at the suture-tendon interface.
Purpose of the Study:
- To evaluate injectable biologic supplementation effects on rotator cuff repair.
- To assess the quality and reporting standards of relevant studies.
Main Methods:
- Systematic review of 40 studies (29 preclinical, 11 clinical) following PRISMA guidelines.
- Assessment of study quality, risk of bias, and adherence to MIBO guidelines.
- Analysis of biomechanical, histological, and clinical outcomes including retear rates.
Main Results:
- Preclinical studies frequently showed improved biomechanical properties and collagen quality.
- Clinical studies reported no adverse events, with similar or improved patient outcomes.
- Specific techniques and adipose-derived mesenchymal stem cells (ADSCs) showed reduced retear rates.
Conclusions:
- Injectable biologics demonstrate positive biomechanical and histological effects.
- Innovative delivery methods and ADSCs show potential for reducing rotator cuff retears.
- Further research adhering to reporting guidelines is warranted.
