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Empagliflozin in Adults with Chronic Kidney Disease (CKD): Current Evidence and Place in Therapy

Gates B Colbert1, Hector M Madariaga2, Anna Gaddy3

  • 1Texas A&M University College of Medicine at Dallas, Dallas, TX, USA.

Therapeutics and Clinical Risk Management
|February 9, 2023
PubMed

Insights

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, like empagliflozin, are revolutionizing chronic kidney disease treatment. Originally for diabetes, they now show significant benefits for cardiovascular and kidney health in diverse patient groups.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Chronic kidney disease (CKD) management has evolved significantly.
  • Sodium-glucose co-transporter 2 (SGLT2) inhibitors have emerged as key therapies beyond hyperglycemia control.
  • Empagliflozin exemplifies this shift, demonstrating broad therapeutic potential.

Purpose of the Study:

  • To review the therapeutic journey of empagliflozin.
  • To highlight its efficacy in cardiovascular and kidney disease endpoints.
  • To discuss implications for patients with and without diabetes.

Main Methods:

  • Review of clinical trials focusing on empagliflozin.
  • Analysis of data from studies investigating hard cardiovascular and kidney outcomes.
  • Inclusion of data from diverse patient populations, including those with and without diabetes.

Main Results:

  • Empagliflozin demonstrates significant benefits for cardiovascular and kidney outcomes.
  • Favorable results observed in patients with and without diabetes.
  • The drug's impact extends beyond glucose-lowering effects.

Conclusions:

  • Empagliflozin represents a major advancement in CKD and cardiovascular disease management.
  • Its utility is established in both diabetic and non-diabetic populations.
  • Further research into SGLT2 inhibitors, including empagliflozin, is warranted for new indications.
Keywords:
SGLT2cardiovascular diseasechronic kidney diseasediabetesempagliflozinend stage kidney disease

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