Related Experiment Video
Updated: Jun 17, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol-Sensitive Release Platform
Tetiana Studer1, Daria Morina1, Inga S Shchelik1
1Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Abstract:
This study reports on the design and engineering of biohybrid microswimmers exploiting a thiol-mediated self-immolative antibiotic release strategy. The design features a covalent attachment of a vancomycin conjugate via a disulfide-based linker to the surface of the microalgae Chlamydomonas reinhardtii. The antibiotic release from the surface of these biohybrids was triggered by the addition of a thiol-based reducing agent, and, subsequently, the inhibition of bacterial growth was observed for Bacillus subtilis and Staphylococcus aureus. These engineered microbots represent the first example of a microalgae-based drug delivery system with a thiol-mediated, reductive release of an antibiotic drug.
More Related Videos
Related Concept Videos
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Production of Pharmaceuticals

