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Inflammatory factors, not complete blood count (CBC) parameters, are elevated in acne vulgaris patients, increasing with acne severity. This suggests inflammatory markers may objectively assess acne grades.

Keywords:
acne vulgarisderived neutrophil-to-lymphocyte ratioinflammatory factorslymphocyte to monocyte ratiosystemic immune-inflammation index

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Area of Science:

  • Dermatology
  • Immunology
  • Hematology

Background:

  • Acne vulgaris is a common skin condition with varying severity.
  • Inflammatory processes play a key role in acne pathogenesis.
  • Objective markers for assessing acne severity are needed.

Purpose of the Study:

  • To compare complete blood count (CBC) parameters and inflammatory factors in acne vulgaris patients of different grades versus healthy controls.
  • To evaluate the utility of inflammatory factors as objective markers for acne severity.

Main Methods:

  • 20 acne vulgaris patients (mild and moderate-to-severe groups) and healthy controls were enrolled.
  • Inflammatory factors (TNF-α, IL-6, IL-8, IL1-α) were measured using ELISA.
  • Complete blood count parameters (MPV, NLR, dNLR, PLR, LMR, SII) were analyzed.

Main Results:

  • Complete blood count parameters showed no significant differences between acne patients and controls.
  • Inflammatory factors were significantly elevated in acne patients compared to controls.
  • Elevated inflammatory factors correlated positively with acne severity grades.

Conclusions:

  • Inflammatory factors effectively indicate the inflammatory response in acne vulgaris.
  • These factors may serve as novel, objective clinical tools for grading acne severity.
  • Further research is warranted, especially considering antibiotic treatments.