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Plasma Micro-RNA 371 Expression in Early-Stage Germ Cell Tumors: Are We Ready to Move Toward Biology-Based Decision

Muhannad Alsyouf1, Lucia Nappi2, Craig Nichols2

  • 1Department of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|February 9, 2023
PubMed
Abstract

No abstract available in PubMed .

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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