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Updated: Aug 11, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
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Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

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Current and potential roles of RNA modification-mediated autophagy dysregulation in cancer

Hua Huang1, Ruining Pan1, Sijia Wang1

  • 1Center of Excellence for Environmental Safety and Biological Effects, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, Beijing, 100124, China.

Archives of Biochemistry and Biophysics
|February 9, 2023
PubMed

Insights

RNA modification regulates autophagy, a key cellular process, and its dysregulation is crucial in cancer development. Exploring this RNA modification/autophagy axis offers new therapeutic strategies for tumors.

Area of Science:

  • Cellular Biology
  • Oncology
  • Molecular Biology

Background:

  • Autophagy is a vital cellular degradation pathway involved in nutrient recycling and stress adaptation.
  • Autophagy plays a significant role in multiple stages of cancer, including initiation, metastasis, and maintenance.
  • RNA modifications are increasingly recognized as regulators of cellular processes, including autophagy.

Purpose of the Study:

  • To review the role of RNA modification-mediated autophagy regulation in tumorigenesis.
  • To explore the molecular crosstalk between RNA modification and autophagy in cancer development.
  • To discuss the potential of the RNA modification/autophagy axis as a therapeutic target in cancer.

Main Methods:

  • Literature review of autophagy mechanisms and RNA modification pathways.
  • Analysis of the interplay between RNA modifications and core autophagy proteins.
  • Synthesis of current research on the RNA modification/autophagy axis in various cancers.

Main Results:

  • RNA modification can directly influence the expression of key autophagy proteins, leading to autophagy dysregulation.
  • The RNA modification/autophagy axis is implicated in tumorigenesis, metastasis, and malignant state maintenance.
  • This axis also plays a dual role in cancer drug resistance.

Conclusions:

  • Autophagy disorder mediated by RNA modification is a critical mechanism in cancer development.
  • Understanding the RNA modification/autophagy crosstalk provides insights into tumor pathophysiology.
  • Targeting the RNA modification/autophagy axis presents novel therapeutic opportunities for cancer treatment.
Keywords:
Anticancer drug resistanceAutophagyCancerRNA modificationm(6)A

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