A novel approach for developing left bundle branch pacing and left bundle branch block in a canine model
Yiran Hu1,2, Sijing Cheng1, Pengkang He3
1Department of Cardiology, State Key Laboratory of Cardiovascular Disease, The Cardiac Arrhythmia Center, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of Cardiovascular Electrophysiology
|February 9, 2023
Summary
This study introduces a novel canine model for left bundle branch pacing (LBBP) and left bundle branch block (LBBB). The developed "triangle-center" method successfully simulated dyssynchrony and resynchronization, offering a tool for further research.
Area of Science:
- Cardiology
- Electrophysiology
- Animal Models
Background:
- Left bundle branch pacing (LBBP) demonstrates efficacy in treating dyssynchronous heart failure (HF).
- Developing reliable animal models is crucial for understanding pacing mechanisms and improving treatments.
Purpose of the Study:
- To develop a novel approach for creating left bundle branch pacing (LBBP) and left bundle branch block (LBBB) in a canine model.
- To establish a feasible method for simulating clinical cardiac dyssynchrony and resynchronization.
Main Methods:
- A
- triangle-center
- method using tricuspid valve annulus angiography for LBBP implantation in 6 canines.
- Simultaneous retrograde His potential recording and left bundle branch (LBB) ablation were performed.
- Conduction system staining verified the method and assessed LBB ablation site proximity to the left septal fascicle (LSF).
Main Results:
- LBBP implantation and LBB ablation were successfully performed in 6 canines.
- LBB ablation significantly prolonged QRS duration (106.3 ± 8.3 ms), while LBBP shortened LBBB-induced QRS duration to 62.5 ± 5.3 ms.
- Anatomical analysis confirmed LBBP lead placement within the LSF area in all subjects.
Conclusions:
- The novel
- triangle-center
- method provides a stable and feasible canine model for LBBP and LBBB.
- This model effectively simulates clinical cardiac dyssynchrony and resynchronization.
- The model serves as a valuable tool for investigating the physiological benefits of pacing.
