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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
What is the Skeletal System?01:02

What is the Skeletal System?

53.1K
Overview
53.1K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K

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Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

606

Osteoporosis.

Vidya Gopinath1

  • 1Warren Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy St, Jane Brown Ground, Suite 0100, Providence, RI 02903, USA.

The Medical Clinics of North America
|February 9, 2023
PubMed
Summary

Osteoporosis screening is recommended for women over 65, but rates are low. Effective treatments like bisphosphonates significantly reduce fracture risk, despite concerns about side effects.

Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Public Health

Background:

  • Osteoporosis is a prevalent bone disease causing significant illness and death in women.
  • Universal screening is advised for women aged 65 and older, yet adherence is suboptimal.
  • Bisphosphonates are the primary treatment, though their use is decreasing due to rare adverse event concerns.

Purpose of the Study:

  • To highlight the importance of osteoporosis screening in older women.
  • To discuss the role of bisphosphonates in managing osteoporosis.
  • To emphasize the benefits of osteoporosis treatment in preventing fractures.

Main Methods:

  • Literature review on osteoporosis prevalence and screening guidelines.
  • Analysis of bisphosphonate efficacy and safety data.
Keywords:
BisphosphonatesBone densityBone fractureFallsHip fractureMenopauseOsteopeniaOsteoporosis

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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  • Examination of fracture reduction rates with osteoporosis treatment.

    • Main Results:

    • Low screening rates in women over 65.
    • Bisphosphonates remain a key treatment despite usage decline.
    • Osteoporosis treatment markedly lowers the risk of fragility fractures.

    Conclusions:

    • Improving osteoporosis screening rates in elderly women is crucial.
    • The benefits of bisphosphonate therapy outweigh risks for most patients.
    • Effective management of osteoporosis is vital for reducing fracture-related morbidity and mortality.