Related Experiment Video
Updated: Aug 11, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Updates in Cardiovascular Disease Prevention, Diagnosis, and Treatment in Women
Sarah Jones1, Melissa McNeil2, Agnes Koczo3
1Division of General Internal Medicine, University of Pittsburgh Medical Center, Montefiore Hospital, 933 West, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Insights
Cardiovascular disease (CVD) is a leading cause of death for women, with prevention and treatment lagging behind men. Personalized risk assessment using cardiometabolic profiles and advanced imaging can improve women
Area of Science:
- Cardiology
- Women's Health
- Preventive Medicine
Background:
- Cardiovascular disease (CVD) remains the primary cause of mortality for American women.
- Current CVD risk reduction strategies are less effective in women than in men.
- Disparities exist in CVD diagnosis and treatment outcomes between women and men.
Purpose of the Study:
- To emphasize the importance of a woman's cardiometabolic profile in prevention and treatment.
- To highlight the role of coronary artery calcium scores and reproductive/menopause history in risk assessment.
- To address diagnostic and therapeutic gaps in women's cardiovascular care.
Main Methods:
- Review of current literature on CVD in women.
- Analysis of risk assessment tools including cardiometabolic profiles, coronary artery calcium scores, and reproductive/menopause histories.
- Examination of diagnostic and treatment disparities, including specific CVD etiologies like spontaneous coronary artery dissection and microvascular disease.
Main Results:
- Personalized risk assessment incorporating a woman's unique profile can enhance prevention counseling.
- Specific risk enhancers like reproductive factors and menopause status require consideration.
- Delayed diagnosis and suboptimal treatment contribute to poorer outcomes in women.
Conclusions:
- Tailoring CVD prevention and treatment to women's specific needs, including their cardiometabolic profile, is crucial.
- Utilizing advanced risk assessment tools and improved imaging for conditions like spontaneous coronary artery dissection and microvascular disease can mitigate disparities.
- Addressing the unique aspects of CVD in women is essential for improving cardiovascular outcomes.
Abstract:
Cardiovascular disease (CVD) is the leading cause of death for American women. CVD is preventable although risk reduction goals are not achieved for women compared with men. Considering a woman's cardiometabolic profile for prevention counseling and prescribing may help. Coronary artery calcium scores provide additional risk assessment and reproductive and menopause histories identify risk enhancers. Diagnosis of CVD is often delayed, and treatment is less optimal for women compared with men. Differences in presentation and underlying CVD etiology (Including spontaneous coronary artery dissection and microvascular disease) may partially account for these disparities. Improvements in CVD imaging to better diagnose these etiologies may benefit women's care.
More Related Videos
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Related Concept Videos
Coronary Artery Disease IV: Preventive Measures
Coronary Artery Disease V: Interprofessional Care
Cardiomyopathy V: Interprofessional Care
Peripheral Artery Disease III: Interprofessional Care
Cardiovascular Drugs: Classification based on Therapeutic Indications
Rheumatic Heart Disease III: Medical Management