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Updated: Aug 11, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Affirming Care for Transgender Patients
Rebecca Green1, Kristen L Eckstrand2, Morgan Faeder3
1Department of Medicine, University of Pittsburgh School of Medicine, UPMC General Internal Medicine Clinic, Montefiore 9S, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
This primer provides an overview of medical gender affirmation for transgender, nonbinary, and gender diverse individuals. It covers essential topics like hormone therapy, surgical options, and fertility preservation for inclusive healthcare.
Area of Science:
- Medical Science
- Endocrinology
- Gender Studies
Background:
- Gender identity is an internal sense of self, distinct from assigned sex at birth.
- Transgender, nonbinary, and gender diverse individuals may pursue medical gender affirmation.
- Understanding terminology and creating inclusive environments are crucial for effective care.
Purpose of the Study:
- To provide a comprehensive primer on the medical care of transgender individuals.
- To outline key aspects of medical gender affirmation.
- To serve as a foundational resource for healthcare providers.
Main Methods:
- Literature review and synthesis of current medical practices.
- Discussion of established guidelines for hormone therapy and surgical interventions.
- Exploration of fertility preservation and cancer screening considerations.
Main Results:
- Medical gender affirmation encompasses hormone therapy, surgical procedures, and supportive care.
- Fertility preservation options should be discussed prior to initiating medical interventions.
- Regular cancer screening tailored to affirmed gender and individual risk factors is recommended.
Conclusions:
- Comprehensive medical care for transgender individuals requires a multidisciplinary approach.
- Knowledge of gender-affirming treatments, fertility, and screening is essential for providers.
- This primer aims to enhance the quality and accessibility of transgender healthcare.
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