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Serum tryptophan and cataract.

R C Augusteyn¹, A Boyd, N Carroll

¹Russell Grimwade School of Biochemistry, University of Melbourne.

Australian and New Zealand Journal of Ophthalmology

|August 1, 1987

Summary

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This study found no significant difference in serum tryptophan levels between cataract patients and healthy individuals. These findings do not support previous research suggesting elevated tryptophan in those with cataracts.

Area of Science:

Biochemistry
Ophthalmology
Clinical Nutrition

Background:

Serum tryptophan, an essential amino acid, has been investigated for its potential role in cataractogenesis.
Previous studies suggested an elevation in serum tryptophan concentrations in individuals with cataracts.

Purpose of the Study:

To investigate and compare total serum tryptophan concentrations in patients with cataracts and healthy control subjects.
To evaluate the association between serum tryptophan levels and the presence of cataracts.

Main Methods:

Serum samples were collected from 74 patients diagnosed with cataracts and 124 healthy control individuals.
Total serum tryptophan concentrations were quantified using a standardized biochemical assay.
Statistical analysis was performed to compare mean values and ranges between the two groups.

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Main Results:

No statistically significant difference was observed in the mean serum tryptophan concentrations between cataractous patients (11.4 +/- 2.6 µg/ml) and control subjects (11.3 +/- 2.2 µg/ml).
The range of serum tryptophan values was also comparable between the cataractous group (7.4-17.1 µg/ml) and the control group (7.3-17.4 µg/ml).

Conclusions:

The current study's findings do not support previous reports of elevated serum tryptophan in cataractous subjects.
Serum tryptophan levels do not appear to be a significant differentiating factor between cataract patients and healthy individuals based on this cohort.