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[Development and Verification of an irAEs Self-Reported Interview System(ISRIS)].
Akiko Yano1, Shizuka Ido, Satomi Sumikawa
1Division of Pharmacy, Ehime University Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 10, 2023
Summary
The immune-related adverse event self-reported interview system (ISRIS) aids early detection of skin issues during immunotherapy. However, it needs improvement for identifying organ-specific toxicities like myocarditis and dysfunction.
Area of Science:
- Oncology
- Immunology
- Clinical Pharmacology
Context:
- Immune checkpoint inhibitors (ICIs) are crucial cancer therapies.
- Immune-related adverse events (irAEs) can complicate ICI treatment.
- Early detection of irAEs is vital for treatment continuity.
Purpose:
- To evaluate the effectiveness of the immune-related adverse event self-reported interview system (ISRIS) for early irAE detection in outpatients receiving ICIs.
- To identify the strengths and limitations of ISRIS in detecting various irAEs.
Summary:
- A retrospective study analyzed 140 outpatients receiving pembrolizumab, nivolumab, atezolizumab, ipilimumab, or durvalumab from June 2019 to May 2020.
- The ISRIS system, administered via tablet, collected data on primary disease, initial irAE symptoms, and detected irAEs.
- ISRIS demonstrated utility in detecting subjective skin disorders but showed low detection rates for myocarditis and thyroid, hepatic, and renal dysfunction.
Impact:
- The ISRIS system shows promise for improving the early identification of specific immune-related adverse events.
- Further development is underway to enhance ISRIS sensitivity and specificity for comprehensive irAE monitoring.
- Optimized irAE detection can facilitate timely intervention, improving patient outcomes and treatment adherence during immunotherapy.
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