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The interplay between the nerves and skeleton: a 30-year bibliometric analysis.
Hongxiang Mei1, Yumeng Wu1, Qingchen Feng1
1State Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Annals of Translational Medicine
|February 10, 2023
Summary
Bibliometric analysis reveals a surge in nerve-bone interaction research, with the United States leading. Future hotspots include osteoarthritis and neuropeptide Y, offering potential therapeutic targets.
Area of Science:
- Nervous System and Skeletal Biology
- Biomedical Research Trends
- Bibliometric Analysis
Background:
- Nerve-bone interactions are a significant area of scientific inquiry.
- Understanding these mechanisms is crucial for advancing skeletal research.
Purpose of the Study:
- To conduct a bibliometric analysis of nerve-bone interaction research.
- To identify current research trends, key contributors, and emerging hotspots.
- To guide future research directions in this field.
Main Methods:
- Analyzed 1989 articles and reviews from Web of Science Core Collection (1991-2022).
- Utilized R (Bibliometrix) and CiteSpace for bibliometric analysis.
- Examined publication trends, influential institutions, authors, journals, and national networks.
Main Results:
- Significant increase in publications over the past decade.
- United States and University of Minnesota are leading country and institution.
- Key journals include *Bone* and *Journal of Bone and Mineral Research*.
- Hot topics include neuromodulation, stem cell differentiation, osteoarthritis, neuropeptide Y, and osteoclastogenesis.
Conclusions:
- Bibliometrics provides an objective assessment of nerve-bone interaction research.
- Identified research frontiers and hotspots for future investigation.
- Highlights the importance of neurovascular crosstalk in skeletal diseases for potential therapeutic targets.
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