Progress in the cryoablation and cryoimmunotherapy for tumor

Area of Science:

• Oncology
• Immunology
• Minimally Invasive Surgery

Background:

• Cryoablation is increasingly utilized for tumor treatment, particularly for early-stage or unresectable cancers.
• It presents advantages in efficacy and safety compared to microwave and radiofrequency ablation (RFA).
• Cryoablation induces tumor cell death and releases tumor antigens, activating anti-tumor immune responses.

Purpose of the Study:

• To review the immune effects of cryoablation.
• To explore the mechanisms and efficacy of combining cryoablation with cancer immunotherapy.
• To examine clinical research on this combination therapy for tumor treatment.

Main Methods:

• Review of existing literature on cryoablation and cancer immunotherapy.
• Analysis of studies investigating cryoablation-induced immune responses.
• Evaluation of clinical trials assessing combination therapy outcomes.

Main Results:

• Cryoablation causes tumor necrosis and apoptosis, releasing autoantigens that stimulate host immunity.
• This immune activation can lead to regression of primary tumors and distant metastases (accompanying effects).
• Cryoablation serves as a basis for combined ablation and immunotherapy strategies.

Conclusions:

• Cryoablation has significant immunomodulatory effects, enhancing anti-tumor responses.
• Combining cryoablation with immunotherapy shows promise for improved cancer treatment outcomes.
• Further clinical research is warranted to optimize this synergistic therapeutic approach.