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Evaluation of pro-atherogenic lipid profile and high atherohenic indexes in patients with Behçet's disease: A

Onur Acar1, Gulhan Aksoy Sarac2, Didem Dinçer Rota2

  • 1Ağrı Provincial Health Directorate, Republic of Turkey, Ministry of Health, Ağrı, Turkey.

Journal of Cosmetic Dermatology
|February 10, 2023
PubMed

Insights

Patients with Behçet's disease exhibit a pro-atherogenic lipid profile, characterized by higher triglycerides and LDL-C, and lower HDL-C. This indicates an elevated cardiovascular disease risk due to atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Clinical Biochemistry

Background:

  • Behçet's disease is a chronic systemic autoimmune and autoinflammatory condition.
  • Patients with Behçet's disease face a significant risk of comorbidities, particularly cardiovascular diseases.
  • Genetic and environmental factors contribute to the pathogenesis of Behçet's disease.

Purpose of the Study:

  • To investigate the relationship between serum lipid parameters and atherogenic indexes in Behçet's disease patients.
  • To evaluate the cardiovascular risk status in individuals with Behçet's disease.
  • To identify key lipid markers associated with atherosclerosis risk in Behçet's disease.

Main Methods:

  • A single-center, retrospective case-control study design.
  • Inclusion of 212 patients over 18 years of age, divided into 106 cases (Behçet's disease) and 106 controls.
  • Analysis of serum lipid parameters and atherogenic indexes.

Main Results:

  • Significant differences in lipid profiles were observed between Behçet's disease patients and controls.
  • Patients with Behçet's disease showed higher serum triglyceride, total cholesterol, LDL-C, and non-HDL-C levels.
  • Elevated levels of Atherogenic Index of Plasma (AIP), Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II), and Atherogenic Coefficient (AC) were found in Behçet's disease patients.
  • Lower high-density lipoprotein cholesterol (HDL-C) levels were noted in patients with Behçet's disease.

Conclusions:

  • Behçet's disease patients present with a pro-atherogenic lipid profile and elevated atherogenic indexes.
  • These findings suggest a high risk for developing atherosclerosis and associated cardiovascular diseases in patients with Behçet's disease.
  • Monitoring lipid parameters and atherogenic indexes is crucial for cardiovascular risk assessment in Behçet's disease management.
Abstract

Keywords:
Behçet's diseaseatherogenic indexesatherogenitycardiac riskinflammation

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