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Updated: Aug 10, 2025

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A Novel In Vitro Wound Healing Assay to Evaluate Cell Migration
Published on: March 17, 2018
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Targeting NRF2 to promote epithelial repair
1Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.
Biochemical Society Transactions
|February 10, 2023
Summary
The transcription factor NRF2 regulates cellular stress responses and promotes tissue repair, particularly in epithelial cells. This review explores NRF2
Area of Science:
- Cellular Biology
- Molecular Biology
- Regenerative Medicine
Background:
- The transcription factor NRF2 is a key regulator of the cellular stress response.
- NRF2 activation is investigated for its potential in preventing tissue injury and promoting repair.
- Epithelial cells play a crucial role in tissue repair through proliferation and migration.
Approach:
- This review synthesizes current research on the role of NRF2 in epithelial tissue repair.
- It examines how NRF2 influences the processes of proliferation and migration in epithelial cells post-injury.
- The review highlights identified NRF2 target genes involved in epithelial repair mechanisms.
Key Points:
- NRF2 governs the repair of epithelial tissues following injury.
- Activation of NRF2 supports epithelial cell proliferation and migration essential for repair.
- Numerous NRF2 targets with diverse functions in epithelial repair are identified.
Conclusions:
- NRF2 is a critical factor in the repair of epithelial tissues.
- Understanding NRF2's role offers therapeutic strategies for enhancing tissue regeneration.
- Further research into NRF2 targets will elucidate mechanisms of epithelial repair.
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