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Targeting NRF2 to promote epithelial repair

Paul Hiebert1, Sabine Werner1

  • 1Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

Biochemical Society Transactions
|February 10, 2023
PubMed

Insights

The transcription factor NRF2 regulates cellular stress responses and promotes tissue repair, particularly in epithelial cells. This review explores NRF2

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • The transcription factor NRF2 is a key regulator of the cellular stress response.
  • NRF2 activation is investigated for its potential in preventing tissue injury and promoting repair.
  • Epithelial cells play a crucial role in tissue repair through proliferation and migration.

Approach:

  • This review synthesizes current research on the role of NRF2 in epithelial tissue repair.
  • It examines how NRF2 influences the processes of proliferation and migration in epithelial cells post-injury.
  • The review highlights identified NRF2 target genes involved in epithelial repair mechanisms.

Key Points:

  • NRF2 governs the repair of epithelial tissues following injury.
  • Activation of NRF2 supports epithelial cell proliferation and migration essential for repair.
  • Numerous NRF2 targets with diverse functions in epithelial repair are identified.

Conclusions:

  • NRF2 is a critical factor in the repair of epithelial tissues.
  • Understanding NRF2's role offers therapeutic strategies for enhancing tissue regeneration.
  • Further research into NRF2 targets will elucidate mechanisms of epithelial repair.
Keywords:
Keap1NRF2cell proliferationcytoprotectiontissue repairwound healing

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