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The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized

Mohammad Reza Amini1, Nastaran Payandeh2, Fatemeh Sheikhhossein3

  • 1Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|February 10, 2023
PubMed

Insights

Fenugreek seed supplementation may lower systolic blood pressure (SBP), but not diastolic blood pressure (DBP). Optimal results were seen with higher doses (≥15g/day) and shorter durations (≤12 weeks) in a meta-analysis of randomized controlled trials.

Area of Science:

  • Nutritional Science
  • Cardiovascular Health
  • Evidence-Based Medicine

Background:

  • Cardiovascular diseases (CVDs) are a significant global health concern.
  • Hypertension (HTN), a common CVD, necessitates effective management strategies.
  • Fenugreek (Trigonella foenum-graecum) has emerged as a potential natural intervention for HTN.

Approach:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
  • Searched major databases (MEDLINE, Cochrane, EMBASE, Web of Science) up to June 2022.
  • Analyzed data from six RCTs involving 373 participants to assess fenugreek's impact on SBP and DBP.

Key Points:

  • Fenugreek seed supplementation significantly reduced systolic blood pressure (SBP) (WMD: 3.46 mmHg, P=0.018).
  • No significant effect was observed on diastolic blood pressure (DBP) (WMD: 3.19 mmHg, P=0.488).
  • Subgroup analyses indicated significant SBP and DBP reduction with fenugreek dosages ≥ 15 g/day and durations ≤ 12 weeks.

Conclusions:

  • Fenugreek seed supplementation may contribute to reducing SBP, particularly at higher doses and shorter durations.
  • The effect on DBP requires further investigation.
  • Clinical relevance of fenugreek for blood pressure management warrants additional research.
Abstract

Keywords:
DBPDiastolic blood pressureFenugreek seedSBPSystolic blood pressure

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