Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

137
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
137
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

107
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
107
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

1.5K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
1.5K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

90
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
90
Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

213
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
213

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning four decades of human migration.

Nature·2026
Same author

Modelling global trade with optimal transport.

Nature communications·2026
Same author

Neural parameter calibration and uncertainty quantification for epidemic forecasting.

PloS one·2024
Same author

Inferring networks from time series: A neural approach.

PNAS nexus·2024
Same author

Scaling digital twins from the artisanal to the industrial.

Nature computational science·2024
Same author

Statistical finite elements for misspecified models.

Proceedings of the National Academy of Sciences of the United States of America·2020
Same journal

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4<sup>+</sup> T cell receptor repertoire.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Wave propagation in fluid-saturated nanoporous media: Upscaling molecular mechanics into continuum-level description.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Knotted solid tori in contact manifolds.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Biophysical fitness landscape design traps viral evolution.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Cryo-EM of the eukaryotic purine transporter UapA demonstrates intramolecular and lipid regulation of transport.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Aug 10, 2025

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

1.1K

Neural parameter calibration for large-scale multiagent models.

Thomas Gaskin1, Grigorios A Pavliotis2, Mark Girolami3,4

  • 1Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK.

Proceedings of the National Academy of Sciences of the United States of America
|February 10, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a fast and simple computational method using neural differential equations to accurately estimate parameters in complex models. The technique significantly improves accuracy and speed for systems in epidemiology and economics.

Keywords:
model calibrationmultiagent systemsneural differential equationsparameter density estimation

More Related Videos

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.4K
A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.4K

Related Experiment Videos

Last Updated: Aug 10, 2025

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

1.1K
Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.4K
A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.4K

Area of Science:

  • Computational Science
  • Quantitative Modeling
  • Machine Learning

Background:

  • Complex systems in quantitative sciences often require parameter estimation from data.
  • Existing parameter estimation methods can be mathematically complex and computationally intensive.
  • Models in social sciences, economics, and epidemiology frequently face these challenges.

Purpose of the Study:

  • To present a computationally simple and fast method for accurate parameter density estimation.
  • To utilize neural differential equations for parameter inference.
  • To develop a pipeline combining multiagent models and neural networks for efficient parameter retrieval.

Main Methods:

  • Developed a pipeline integrating multiagent models as forward solvers for differential equations.
  • Employed a neural network to extract parameters from model-generated data.
  • Applied the method to synthetic time series data of the SIR model and the Harris-Wilson economic model.

Main Results:

  • The method accurately estimates probability densities for model parameters, even in large systems.
  • Demonstrated effectiveness on both synthetic and real-world economic activity data.
  • Achieved orders of magnitude greater accuracy and significantly faster computation compared to classical techniques for the Harris-Wilson model.

Conclusions:

  • The proposed method offers a computationally efficient and accurate approach to parameter estimation in complex systems.
  • Neural differential equations provide a powerful tool for inferring model parameters in diverse scientific domains.
  • This approach accelerates the analysis of complex models in fields like epidemiology and economics.