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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Aug 10, 2025

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

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Early Fractional Ablative Laser for Skin Cancer Excision Scars: A Randomized Split-Scar Study.

Matthew J Lin1, Danielle P Dubin1, Richard L Torbeck1

  • 1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|February 10, 2023
PubMed
Summary
This summary is machine-generated.

Fractional CO2 laser treatment for surgical scars on Day 0 or Day 14 yields similar cosmetic outcomes. This study found no significant difference in patient or physician assessments for early versus delayed laser resurfacing.

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Regenerative Medicine

Background:

  • Fractional ablative laser resurfacing is recognized for improving surgical scar appearance.
  • The optimal timing for initiating fractional CO2 laser treatment remains undetermined.

Purpose of the Study:

  • To compare the efficacy of fractional carbon dioxide (CO2) laser treatment for surgical scars when applied on Day 0 versus Day 14 post-operatively.

Main Methods:

  • A prospective, randomized, split-scar, physician-blinded study involved 30 surgical scars on limbs.
  • Scars were treated with fractional CO2 laser on either Day 0 or Day 14.
  • Assessments at 6 months included patient preference, physician-modified Manchester Scar Scale (MMSS) scores, and quantitative histological analysis (fractal dimension and lacunarity).

Main Results:

  • No significant differences were observed in patient preference (54% Day 0 vs. 46% Day 14, p = .58) or physician assessments (MMSS: 8.4 Day 0 vs. 8.7 Day 14, p = .28).
  • Quantitative histological analysis showed similar fractal dimensions (p = .80) and lacunarity (p = .44) between the two treatment timings.

Conclusions:

  • Intraoperative fractional CO2 laser treatment is noninferior to treatment on Day 14 for improving surgical scar appearance.
  • The timing of fractional CO2 laser application (immediate vs. delayed) does not significantly impact scar outcomes.