Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.7K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.7K
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

13.9K
In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or...
13.9K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.6K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunalysis tapentadol assay reformulation resolves tramadol interference.

Journal of analytical toxicology·2025
Same author

On-Cell Stability of Digoxin, Lithium, Phenytoin, Valproic Acid, and Vancomycin for Therapeutic Drug Monitoring.

The journal of applied laboratory medicine·2025
Same author

Practical Considerations for Implementing Targeted Mass Spectrometry for Urine Drug Testing in Clinical Laboratories.

Clinics in laboratory medicine·2025
Same author

Rainbow phlebotomy collection and urine aliquots for emergency department add-on testing in the era of pandemic-driven supply shortages.

Laboratory medicine·2024
Same author

Reference intervals: past, present, and future.

Critical reviews in clinical laboratory sciences·2023
Same author

Precision quality control: a dynamic model for risk-based analysis of analytical quality.

Clinical chemistry and laboratory medicine·2023
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
Same journal

Updates in Antiphospholipid Syndrome Laboratory Diagnosis.

Clinics in laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: Aug 10, 2025

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:30

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

148

Artificial Intelligence Applications in Clinical Chemistry.

Dustin R Bunch1, Thomas Js Durant2, Joseph W Rudolf3

  • 1Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, 700 Children's Drive, C1923, Columbus, OH 43205-2644, USA; Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Clinics in Laboratory Medicine
|February 10, 2023
PubMed
Summary
This summary is machine-generated.

This review examines how artificial intelligence is being used to improve laboratory testing, from identifying collection errors to predicting patient results and streamlining workflows, while acknowledging the ethical and operational hurdles that must be addressed.

Keywords:
Artificial intelligenceClinical chemistryExpert systemsMachine learningmachine learninglaboratory automationpredictive analyticsdiagnostic testing

Frequently Asked Questions

More Related Videos

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

2.2K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.6K

Related Experiment Videos

Last Updated: Aug 10, 2025

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:30

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

148
Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence
09:11

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Published on: January 27, 2023

2.2K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.6K

Area of Science:

  • Artificial intelligence integration within clinical chemistry diagnostics
  • Laboratory medicine and pathology informatics

Background:

No prior work has fully synthesized the rapid expansion of machine learning tools across all diagnostic laboratory phases. Researchers currently lack a comprehensive overview of how these automated systems impact daily clinical operations. It was already known that computational models offer potential improvements for specimen handling and result interpretation. However, the specific integration of these technologies into standard testing pipelines remains fragmented in the literature. That uncertainty drove the need for a systematic evaluation of current digital advancements. Prior research has shown that automated algorithms can identify anomalies in patient samples with high accuracy. This gap motivated a closer look at how these innovations alter traditional workflows. The field requires a clear perspective on the current state of these sophisticated digital implementations.

Purpose Of The Study:

The aim of this review is to evaluate the current landscape of digital intelligence applications within diagnostic laboratory medicine. Researchers sought to clarify how these emerging tools impact various stages of the testing process. This study addresses the motivation to understand the potential benefits of automation in clinical settings. The authors examine how computational models might resolve persistent issues like specimen collection errors. They also investigate the role of predictive analytics in improving diagnostic speed and accuracy. The work explores the operational and ethical hurdles that accompany the adoption of these advanced systems. By synthesizing existing publications, the study provides a clear view of the field's current trajectory. This effort serves to guide future discussions on integrating digital solutions into standard laboratory practice.

Main Methods:

Review approach involved a comprehensive synthesis of existing literature regarding digital diagnostic tools. Investigators examined publications detailing machine learning implementations across diverse testing environments. The study design focused on categorizing applications into preanalytic, analytic, and postanalytic segments. Researchers evaluated evidence concerning specimen error detection and predictive result modeling. The team assessed reports on workflow optimization and autoverification enhancements. This systematic overview prioritized peer-reviewed findings that demonstrated clear technological utility. The methodology excluded anecdotal evidence to ensure a robust summary of current capabilities. Experts synthesized these findings to provide a cohesive narrative on the state of laboratory automation.

Main Results:

Key findings from the literature demonstrate that computational models successfully identify common specimen collection errors. Research indicates these systems significantly improve the accuracy of predicting laboratory results and patient diagnoses. Data shows that autoverification workflows benefit from enhanced automation, reducing the burden on laboratory staff. The literature confirms that these applications span all phases of the testing cycle. Evidence suggests that digital tools provide a consistent performance boost compared to traditional manual methods. Studies highlight that these innovations are currently under active investigation across various clinical settings. The findings reveal that while performance is promising, the integration remains in a developmental stage. Researchers report that these technologies are poised to alter standard operating procedures within the medical field.

Conclusions:

The authors propose that digital intelligence will fundamentally reshape diagnostic laboratory operations in the coming years. Synthesis and implications suggest that these tools hold significant potential for optimizing every stage of testing. Researchers highlight that addressing ethical dilemmas is a prerequisite for widespread clinical adoption. The review indicates that operational hurdles currently limit the seamless integration of these advanced systems. Experts emphasize that predictive modeling could enhance diagnostic accuracy across diverse patient populations. The literature suggests that autoverification processes will become increasingly reliant on these automated frameworks. Authors conclude that the transition toward digital-first laboratories is inevitable despite existing implementation barriers. Future efforts must focus on balancing technological innovation with rigorous oversight and standardized protocols.

The researchers propose that these systems improve testing by identifying specimen collection errors, forecasting patient results, and optimizing autoverification workflows. Unlike manual oversight, these automated tools offer continuous monitoring across preanalytic, analytic, and postanalytic phases.

The authors highlight that ethical dilemmas and operational barriers represent the primary obstacles. While these technologies offer promise, they require careful management compared to traditional methods that rely solely on human intervention.

The authors suggest that these computational models are necessary for managing the increasing volume and complexity of laboratory data. Without such automation, laboratories may struggle to maintain efficiency compared to facilities utilizing advanced predictive analytics.

The review indicates that predictive modeling plays a role in forecasting diagnoses and laboratory values. This data-driven approach allows for more proactive clinical decision-making compared to reactive testing strategies.

The researchers observe that these tools enhance autoverification workflows by reducing manual review requirements. This measurement of efficiency shows a shift toward automated validation compared to legacy systems that demand significant technician time.

The authors propose that these technologies will transform the practice of the laboratory in the near future. This implication suggests a shift toward digital-centric operations compared to the current reliance on manual processes.