[Morphologic and biochemical changes in brain cells of mice with influenza]

The influence of influenza virus infection on the brain cells was studied in mice. Virology, electron microscopy and biochemistry methods were used for this purpose. It has been shown that intracerebral injection of pathogenic strain of influenza virus A/PR/8/34 is accompanied both by the reproduction of virus in the central nervous system tissue and the morphology changes in ependial cells of the vascular plexus of the brain lateral ventricle. It has been found that the level of the lipid peroxidation products in lipid extracts of infected mouse brain is greater than their level in extracts from control mouse brain. It has been concluded that the influenza virus has a damaging effect on the central nervous system cells.