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Iranian school-aged twin registry: preliminary reports and project progress
Hamidreza Abtahi1, Marsa Gholamzadeh2,3, Roza Baharii4
1Pulmonary and Critical Care Medicine Department, Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
BMC Pediatrics
|February 11, 2023
Summary
The National Persian Twin Registry successfully enrolled over 5,000 twin pairs, establishing a valuable resource for future twin studies. Preliminary data indicate a high rate of dizygotic twins, requiring further verification.
Area of Science:
- * Epidemiology
- * Genetics
- * Biostatistics
Background:
- * The National Persian school-aged twin registry was established to facilitate twin research.
- * This report details the registry's characteristics, database design, and initial findings from its first phase.
Purpose of the Study:
- * To establish a national platform for school-aged twin studies in Iran.
- * To describe the registry's foundational elements and preliminary data collection outcomes.
Main Methods:
- * Data elements and collection processes were defined through focus group discussions.
- * Twin data were sourced from the Ministry of Education's electronic database, with Tehran schools participating initially.
- * Parents completed standardized questionnaires on demographics and twin similarity; data analyzed using SPSS v.22.
Main Results:
- * Established in 2018, the registry identified 189,738 school-aged students born between 2003-2017.
- * The first phase enrolled 5,642 twin pairs (9,772 individuals), 906 triples, and 92 quadruplets.
- * Zygosity analysis revealed 14% of twin pairs were monozygotic.
Conclusions:
- * Recruitment via school health assistants proved effective for high enrollment and cost reduction.
- * The registry identified a high proportion of dizygotic twins, necessitating bio-sample verification in subsequent research phases.
