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In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells
Faraz Chamani1, Marla M Pyle2, Tej B Shrestha2,3
1Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS 66506, USA.
Cancers
|February 11, 2023
Summary
This study investigated thermal injury kinetics in pancreatic cancer cells. The Arrhenius model with time delay accurately predicted heat-induced damage, aiding thermal therapy development for pancreatic cancer.
Area of Science:
- Oncology
- Biophysics
- Biotechnology
Background:
- Thermal therapies are explored for pancreatic cancer treatment.
- Understanding thermal injury kinetics is crucial for optimizing hyperthermia strategies.
Purpose of the Study:
- To determine the kinetics of thermal injury in pancreatic cancer cells in vitro.
- To evaluate predictive models for thermal injury in pancreatic cancer treatment.
Main Methods:
- Assessed cell viability of murine pancreatic cancer (KPC, Pan02) and fibroblast (STO) cell lines after heating (42.5-50 °C for 3-60 min).
- Utilized kinetic parameters from viability data to predict heat-induced cellular damage.
- Compared three thermal injury models, including the Arrhenius model with time delay.
Main Results:
- The Arrhenius model with time delay demonstrated the highest prediction accuracy (RMSE = 8.48%) across all cell lines.
- Pancreatic cancer cell line Pan02 showed resistance to hyperthermia, while STO fibroblasts were most susceptible.
- Established kinetic parameters for thermal injury in pancreatic cancer and normal cells.
Conclusions:
- The Arrhenius model with time delay is a reliable tool for predicting thermal damage in pancreatic cancer cells.
- Cell line-specific responses to hyperthermia were observed, highlighting the need for tailored treatment planning.
- Findings support the integration of thermal therapies into multi-modality treatment strategies for pancreatic cancer.
