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Epigenetic Perspective of Immunotherapy for Cancers
Sunita Keshari1, Praveen Barrodia2, Anand Kamal Singh2
1Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Epigenomic events in the tumor immune microenvironment (TIME) are key to overcoming immunotherapy challenges like varied responses and recurrence. Understanding these reversible epigenetic modifications offers new therapeutic strategies for cancer treatment.
Area of Science:
- Immunology
- Oncology
- Epigenetics
Background:
- Immunotherapy offers significant promise for cancer patients.
- Challenges remain, including patient response heterogeneity, disease recurrence, and immune-related adverse effects (iRAEs).
Purpose of the Study:
- To review epigenomic events within the tumor immune microenvironment (TIME).
- To explore the therapeutic potential of epigenetic modifications in improving cancer immunotherapy.
Main Methods:
- Comprehensive review of existing studies linking epigenomic events with immuno-oncology approaches.
- Analysis of epigenomic data in the context of TIME and treatment responses.
Main Results:
- Epigenomic events significantly regulate biomolecules within the TIME.
- Epigenetic modifications are reversible and druggable, offering therapeutic opportunities.
Conclusions:
- Understanding TIME epigenomics is crucial for addressing immunotherapy limitations.
- Targeting epigenetic modifications can enhance cancer immunotherapy for diagnosis, progression, and cure.
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