Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vanadate ions: central nervous system action on glucoregulation.

S Amir1, J Meyerovitch, Y Shechter

  • 1Center for Neurosciences and Behavioral Research, Weizmann Institute of Science, Rehovot Israel.

Brain Research
|September 1, 1987
PubMed
Summary

Central administration of vanadate (VO-3) causes hyperglycemia in mice by stimulating glucose transport in neurons and increasing sympathetic nervous system activity. This highlights vanadate

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial disease management through phytochemical interventions.

Molecular and cellular biochemistry·2025
Same author

Comprehensive Risk Assessment of Infection Induced by SARS-CoV-2.

Molecular neurobiology·2023
Same author

Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review.

International journal of biological macromolecules·2023
Same author

The precarious use of charm needles susuk in treatment of low back pain by traditional medicine practitioners and its possible risk to patient safety.

The Medical journal of Malaysia·2020
Same author

Response to letter of Dawson J. A, Brown A. W and Allison D. B: intervention for childhood obesity based on parents only or parents and child compared to follow-up alone.

Pediatric obesity·2018
Same author

Intervention for childhood obesity based on parents only or parents and child compared with follow-up alone.

Pediatric obesity·2018

Area of Science:

  • Biochemistry
  • Neuroendocrinology
  • Trace Element Research

Background:

  • Vanadate (VO-3) is a trace element with insulin-mimetic properties.
  • Central administration of vanadate can induce hyperglycemia.

Purpose of the Study:

  • To investigate the mechanism by which central vanadate administration leads to hyperglycemia.
  • To determine if vanadate's hyperglycemic effect involves glucose transport and sympathetic nervous system activation.

Main Methods:

  • Central administration of vanadate (VO-3) and vanadyl (VO2+) in mice.
  • Co-administration with agents blocking glucose transport (3-O-methylglucose) or insulin signaling (polymyxin B).
  • Assessment of sympathetic nervous system and epinephrine levels following central vanadate administration.

Related Experiment Videos

Main Results:

  • Vanadate, but not other ions, caused systemic hyperglycemia upon central administration.
  • The hyperglycemic effect was blocked by agents inhibiting glucose transport.
  • Inhibition of central sympathetic outflow or epinephrine levels prevented the vanadate-induced hyperglycemia.

Conclusions:

  • Central vanadate administration influences peripheral glucoregulation via increased sympathetic outflow from the central nervous system (CNS).
  • Vanadate's action is linked to stimulating glucose transport into neuronal cells, mediated by VO-3 or VO2+.