Associations between Different Ozone Indicators and Cardiovascular Hospital Admission: A Time-Stratified...

Epidemiological studies reported that ozone (O₃) is associated with cardiovascular diseases. However, only few of these studies examined the impact of multiple O₃ indicators on cardiovascular hospital admissions. This study aimed to explore and compare the impacts of different O₃ indicators on cardiovascular hospital admissions in Guangzhou, China. Based upon the data on daily cardiovascular hospital admissions, air pollution, and meteorological factors in Guangzhou from 2014 to 2018, a time-stratified case-crossover design model was used to analyze the associations between different O₃ indicators and cardiovascular hospital admissions. Moreover, the sensitivities of different age and gender groups were analyzed for the whole year and different seasons (i.e., warm and cold). During the warm season, for the single-pollutant model, the odds ratio (OR) value of cardiovascular hospital admissions was 1.0067 (95% confidence interval (CI): 1.0037, 1.0098) for every IQR increase in MDA8 O₃ at a lag of five days. The effect of O₃ on people over 60 year was stronger than that on the 15-60 years age group. Females were more sensitive than males to O₃ exposure. These results provided valuable references for further scientific research and environmental improvement in Guangzhou. Given that short-term O₃ exposure poses a threat to human health, the government should therefore pay attention to prevention and control policies to reduce and eliminate O₃ pollution and protect human health.