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The Endocannabinoid System and Physical Exercise.
Daniela Matei1, Dan Trofin1,2, Daniel Andrei Iordan3,4
1Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iasi, 700454 Iasi, Romania.
International Journal of Molecular Sciences
|February 11, 2023
Summary
Physical exercise activates the endocannabinoid system (ECS), releasing endocannabinoids (eCBs). This may explain the "runner
Area of Science:
- Neuroscience and Exercise Physiology
- Endocannabinoid System Research
Background:
- The endocannabinoid system (ECS) regulates numerous physiological processes, including mood, pain, and metabolism.
- Physical exercise (PE) is a non-pharmacological intervention with significant health benefits, including ECS activation.
- Endocannabinoids (eCBs) are released during high-intensity exercise, potentially mediating its mood-altering effects.
Purpose of the Study:
- To review the current understanding of the relationship between endocannabinoids and physical exertion.
- To provide an overview of existing literature on exercise-induced endocannabinoid release and its effects.
Main Methods:
- Literature review of studies investigating the endocannabinoid system and physical exercise.
- Synthesis of findings on endocannabinoid generation during physical activity.
- Analysis of the role of endocannabinoids in phenomena like 'runner's high'.
Main Results:
- Sustained physical exercise, particularly high-intensity activities, triggers the release of endocannabinoids.
- Endocannabinoids contribute to short-term pain relief (antinociception) and may be involved in the 'runner's high' phenomenon.
- The 'runner's high' is associated with mood enhancement, including reduced anxiety and increased euphoria.
Conclusions:
- Physical exercise is a potent modulator of the endocannabinoid system.
- The release of endocannabinoids during exercise offers a potential mechanism for its mood-regulating and analgesic effects.
- Further research into exercise and the ECS could yield novel therapeutic strategies for mental and physical well-being.
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