Tailored Supramolecular Cage for Efficient Bio-Labeling

Fluorescent chemosensors are powerful imaging tools used in a broad range of biomedical fields. However, the application of fluorescent dyes in bioimaging still remains challenging, with small Stokes shifts, interfering signals, background noise, and self-quenching on current microscope configurations. In this work, we reported a supramolecular cage (C) by coordination-driven self-assembly of benzothiadiazole derivatives and Eu(OTf)₃. The C exhibited high fluorescence with a quantum yield (QY) of 38.57%, good photoluminescence (PL) stability, and a large Stokes shift (153 nm). Furthermore, the CCK-8 assay against U87 glioblastoma cells verified the low cytotoxicity of C. We revealed that the designed probes could be used as U87 cells targeting bioimaging.