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Related Experiment Videos

Early postnatal development of monkey subthalamic nucleus: a light and electron microscopic study.

J E Fisher1, T Pasik, P Pasik

  • 1Department of Neurology, Mount Sinai School of Medicine, CUNY, NY 10029.

Brain Research
|November 1, 1987
PubMed
Summary

The subthalamic nucleus in rhesus monkeys undergoes significant synapse elimination during the first four postnatal months. This developmental process involves neuronal changes and a reduction in overall synapse numbers.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Primate Research

Background:

  • The subthalamic nucleus is a crucial component of the basal ganglia motor circuit.
  • Understanding its developmental trajectory is essential for comprehending motor control and related disorders.

Purpose of the Study:

  • To quantitatively analyze the structural and synaptic development of the subthalamic nucleus in rhesus monkeys from birth to 17 weeks.
  • To identify key developmental changes, particularly synapse elimination, within this period.

Main Methods:

  • Light and electron microscopy were employed on subthalamic nuclei from 9 rhesus monkeys (newborn to 17 weeks).
  • Computer-assisted quantitative methods, including stereologic reconstruction (Coupland method), were used to assess neuronal and synaptic parameters.

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  • Measurements included neuronal soma and nucleus size, cell numbers, and synaptic density.

    • Main Results:

    • Subthalamic nucleus volume remained stable, but neuronal soma and nucleus size decreased significantly, especially in the first month.
    • Total cell numbers declined, and dendritic growth cones and axonal degeneration were observed.
    • Synaptic density remained stable in the first month, then declined markedly, reaching 55% of birth levels by 16 weeks, indicating substantial synapse elimination.

    Conclusions:

    • The subthalamic nucleus undergoes significant structural and synaptic remodeling during early postnatal development in rhesus monkeys.
    • Synapse elimination is a prominent feature of this developmental period, impacting the nucleus's circuitry and function.