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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Interactions between Sodium Hyaluronate and β-Cyclodextrin as Seen by Transport Properties
Lenka Musilová1,2, Aleš Mráček1,2, Eduarda F G Azevedo3
1Department of Physics and Materials Engineering, Faculty of Technology, Thomas Bata University in Zlín, Vavrečkova 275, 760 01 Zlín, Czech Republic.
International Journal of Molecular Sciences
|February 11, 2023
Summary
This study reveals how beta-cyclodextrins affect sodium hyaluronate diffusion. We found significant interactions, impacting mass transport crucial for drug delivery and food packaging applications.
Area of Science:
- Biomaterials Science
- Physical Chemistry
Background:
- Hyaluronic acid (HA) and its sodium salt (NaHy) are vital in drug delivery and food packaging.
- Understanding HA/NaHy mass transport with cyclodextrins is crucial but understudied.
- Previous research focused on HA functionalization, not cyclodextrin's effect on HA mass transport.
Purpose of the Study:
- To quantify the effect of beta-cyclodextrins on sodium hyaluronate diffusion.
- To determine tracer binary and ternary interdiffusion coefficients of NaHy in aqueous beta-cyclodextrin solutions.
- To elucidate the interaction mechanisms between NaHy and beta-cyclodextrins.
Main Methods:
- Measurement of tracer binary and ternary interdiffusion coefficients.
- Analysis of sodium hyaluronate (NaHy) diffusion in water and aqueous beta-cyclodextrin solutions.
- Investigation of NaHy reduced viscosity dependence on concentration.
Main Results:
- NaHy diffusion is dependent on its reduced viscosity, showing a minimum at ~2.5 g dm⁻³.
- A significant decrease (up to 45%) in NaHy limiting diffusion coefficient was observed in the presence of beta-cyclodextrin.
- This reduction was most pronounced at NaHy concentrations below 1 g dm⁻³.
Conclusions:
- Sodium hyaluronate (NaHy) exhibits strong interactions with beta-cyclodextrins.
- These interactions significantly influence NaHy's mass transport properties.
- Findings are relevant for optimizing HA-based formulations in drug delivery and food science.
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