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Paraoxonase 1 and Chronic Kidney Disease: A Meta-Analysis
Jun Watanabe1, Kazuhiko Kotani1, Alejandro Gugliucci2
1Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City 329-0498, Japan.
Journal of Clinical Medicine
|February 11, 2023
Summary
Paraoxonase 1 (PON1) enzyme activity is significantly lower in patients with chronic kidney disease (CKD). This impaired antioxidant defense is more pronounced in advanced stages of CKD.
Area of Science:
- Nephrology
- Biochemistry
- Oxidative Stress Research
Background:
- Oxidative stress is implicated in chronic kidney disease (CKD) pathophysiology.
- Paraoxonase 1 (PON1), an antioxidant enzyme, is a potential biomarker for CKD.
- Existing studies suggest an association between serum PON1 activity and CKD, necessitating systematic data analysis.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between PON1 activity and CKD.
- To systematically analyze existing literature on PON1 in non-dialysis CKD patients.
- To establish consensus on PON1's role in CKD pathophysiology.
Main Methods:
- Systematic literature search of MEDLINE, Embase, and CENTRAL databases up to December 2022.
- Inclusion of studies reporting PON1 activity in CKD patients and healthy controls.
- Random-effects meta-analysis of paraoxonase and arylesterase activities.
Main Results:
- A meta-analysis of 24 studies revealed significantly lower paraoxonase activity (SMD, -1.72) and arylesterase activity (SMD, -2.60) in CKD patients compared to controls.
- Subgroup analysis indicated a more pronounced decrease in paraoxonase activity in advanced CKD (chronic kidney failure).
- Variability in PON1 activity reduction was observed based on the substrate used for measurement.
Conclusions:
- PON1 activity is demonstrably reduced in patients with CKD, indicating impaired antioxidant defense.
- The decline in PON1 activity is exacerbated in advanced stages of CKD.
- Further research is warranted to fully elucidate the role and implications of reduced PON1 activity in CKD.
Keywords:
antioxidantsarylesterasecardiovascular diseasekidney failureparaoxonasereactive oxygen speciesMore Related Videos
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