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High-grade mantle zone lymphoma.

D J Ellison1, R R Turner, R Van Antwerp

  • 1University of Southern California, School of Medicine, Los Angeles 90033.

Cancer
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

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This study reports an aggressive Stage IV mantle zone lymphoma (MZL) case with unusual histopathologic features and widespread dissemination. The aggressive lymphoma showed limited response to chemotherapy, highlighting the need for novel therapeutic strategies.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Mantle zone lymphoma (MZL) is a B-cell non-Hodgkin lymphoma.
  • Stage IV MZL typically presents with widespread disease.

Observation:

  • A 66-year-old man presented with night sweats, lymphadenopathy, hepatosplenomegaly, and paraproteinemia.
  • The patient was diagnosed with aggressive Stage IV mantle zone lymphoma.
  • The lymphoma rapidly disseminated to extranodal sites including skin, lungs, pleura, and CNS.

Findings:

  • The neoplasm exhibited an aggressive clinical course and poor response to initial chemotherapy.
  • Histopathologic examination revealed unusual features for MZL: vascular invasion, massive extranodal infiltration, high mitotic count, and convoluted nuclei.
  • Partial response was observed with multi-agent chemotherapy.

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Implications:

  • This case highlights aggressive variants of mantle zone lymphoma with atypical features.
  • The findings suggest potential challenges in treating advanced-stage MZL with conventional chemotherapy.
  • Further research into the biology and treatment of aggressive MZL with these specific histopathologic characteristics is warranted.