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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
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Future Antimicrobials: Natural and Functionalized Phenolics.

Andrei Lobiuc1, Naomi-Eunicia Pavăl1, Ionel I Mangalagiu2

  • 1Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University, 720229 Suceava, Romania.

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|February 11, 2023
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Summary

Functionalizing natural phenolic compounds enhances their antimicrobial activity, offering a promising strategy to combat rising antimicrobial resistance. This approach targets multiple bacterial sites, reducing the minimal concentrations needed for effective treatment.

Keywords:
alkylationesterificationflavonoidslignansminimal inhibitory concentrationtannins

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Area of Science:

  • Natural Product Chemistry
  • Microbiology
  • Medicinal Chemistry

Background:

  • Antimicrobial resistance is a growing global health threat, necessitating novel therapeutic agents.
  • Phenolic compounds possess a versatile chemical structure amenable to modifications that can boost their antimicrobial properties.

Purpose of the Study:

  • To review the functionalization strategies for natural phenolic compounds.
  • To summarize the impact of these modifications on antimicrobial activity.

Main Methods:

  • Review of existing literature on phenolic compound functionalization.
  • Analysis of synthetic routes including esterification, phosphorylation, hydroxylation, and enzymatic conjugation.
  • Examination of the mechanisms of action of functionalized phenolics.

Main Results:

  • Functionalization significantly enhances the antimicrobial efficacy of phenolic compounds.
  • Modified phenolics can target multiple bacterial pathways, including cell wall synthesis and DNA replication.
  • These modifications reduce the minimal inhibitory concentrations required for antimicrobial effect.

Conclusions:

  • Functionalization is a key strategy to develop potent antimicrobial agents from natural phenolics.
  • Targeting multiple bacterial sites increases bacterial susceptibility to these compounds.
  • Further research into functionalized phenolics holds promise for combating antimicrobial resistance.