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Updated: Aug 10, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

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Published on: November 15, 2017

Towards Antibiotic Synthesis in Continuous-Flow Processes.

Marziale Comito^1,2, Riccardo Monguzzi², Silvia Tagliapietra¹

¹Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.

Molecules (Basel, Switzerland)

|February 11, 2023

Summary

This summary is machine-generated.

Continuous-flow chemistry offers a safer, faster, and more efficient method for synthesizing antibiotics. This review highlights key advancements in flow processes for antibiotic production from 2012-2022.

Keywords:

antibiotics continuous process drug synthesis flow chemistry industrial application miniaturization process control

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Area of Science:

Medicinal Chemistry
Chemical Engineering
Organic Synthesis

Background:

Continuous-flow chemistry is a mainstream technology for drug synthesis, offering advantages over batch processes.
Recent years have seen increased focus on its integration with inline analysis and purification for drug development.
Government agencies globally encourage the adoption of this sustainable technology.

Purpose of the Study:

To review and evaluate the development and applications of continuous-flow processes in antibiotic synthesis.
To highlight key examples of active pharmaceutical ingredients (APIs) or intermediates produced via flow chemistry.
To provide an overview of the impact of flow chemistry on antibiotic synthesis.

Main Methods:

Literature review spanning 2012-2022.
Evaluation of continuous-flow processes for antibiotic synthesis.
Identification of key applications in producing antibiotic active ingredients or intermediates.

Main Results:

Continuous-flow chemistry is increasingly adopted for antibiotic synthesis due to its efficiency and safety.
The technology facilitates inline analysis and purification, meeting stringent drug development quality objectives.
Numerous examples demonstrate the successful application of flow chemistry for producing antibiotic compounds and their precursors.

Conclusions:

Continuous-flow chemistry is a vital and evolving technology for modern antibiotic synthesis.
Its adoption aligns with quality, sustainability, and efficiency goals in pharmaceutical manufacturing.
This review serves as a foundation for understanding flow chemistry's significant impact on the antibiotic synthesis landscape.