Association between bisphenol A exposure and thyroid dysfunction in adults: a systematic review and meta-analysis
Shumeng Yuan1, Xingde Du1, Haohao Liu1
1College of Public Health, 12636Zhengzhou University, Zhengzhou, China.
Toxicology and Industrial Health
|February 11, 2023
Summary
Environmental exposure to Bisphenol A (BPA) shows differing effects on thyroid hormones. BPA may decrease thyroid hormones in males but increase them in females, warranting further investigation.
Area of Science:
- Environmental Science
- Endocrinology
- Toxicology
Background:
- Thyroid dysfunction is influenced by environmental factors, with Bisphenol A (BPA) being a widespread pollutant linked to potential thyroid disruption.
- Existing epidemiological evidence on the association between BPA exposure and thyroid dysfunction is inconsistent.
- This study systematically reviews and analyzes the impact of BPA on adult thyroid function.
Approach:
- A comprehensive literature search was conducted on PubMed, Web of Science, and Scopus for studies published up to May 23, 2022.
- Eleven studies investigating the association between BPA exposure and thyroid hormone levels were included after quality assessment.
- Sensitivity, subgroup analyses (by population and gender), and publication bias were evaluated.
Key Points:
- BPA concentration was negatively correlated with free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in males.
- BPA concentration was positively correlated with FT4 in females.
- Significant differences were observed in BPA's effects on thyroid hormone levels between males and females.
Conclusions:
- BPA exposure may decrease FT4 and TSH levels in males and increase FT4 levels in females.
- High heterogeneity among studies and limited subgroup investigations necessitate further research.
- The precise relationship between BPA exposure and thyroid dysfunction requires continued investigation.
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